“There is not any knowledge or science to assist whether or not GLP-1 prolongs life, for instance, will increase lifespan,” says Dr. Rekha Kumar, an endocrinologist and weight problems medication knowledgeable on the Iris Cantor Girls’s Well being Heart in New York Metropolis. “For those who’re questioning whether or not such a medication can maintain you more healthy for longer over your lifetime, the reply is that the science is transferring within the course of supporting it.”
“Cell research present diminished continual irritation, improved mitochondrial operate (mobile vitality), improved vascular operate (blood move), and diminished oxidative stress,” says Dr. Kumar. “All of that is mobile proof that GLP-1 could also be useful.”
In response to Dr. Reshmi Srinath, director of the Mount Sinai Weight and Metabolic Administration Program in New York Metropolis, analysis is being carried out to determine whether or not GLP-1 could have a good higher affect on elements related to growing old.
“Pharmaceutical firms are at present finding out the function of GLP-1 in growing old and immune operate, and additionally it is being studied in autoimmune illnesses and neurological circumstances,” she says.
irritation and growing old
“GLP-1 reduces irritation within the physique,” Kumar says. “The sort of irritation contributes not solely to heart problems, but additionally most cancers, neurodegenerative illnesses (Alzheimer’s and Parkinson’s), and arthritis.”
Coronary heart and organ safety
Most cancers and metabolic well being
“There may be rising curiosity in utilizing GLP to forestall continual illnesses equivalent to most cancers, for sufferers who don’t want weight reduction or diabetes therapy,” Kumar says. “The advantages seem to return from each direct results and enhancements in blood sugar and physique fats.”
mobile growing old
“We are able to hypothesize and extrapolate that this additionally has an impact on mobile growing old,” she says.
Mind well being and neuroprotection
Kumar describes a affected person with a robust household historical past of Alzheimer’s illness who requested to attempt GLP-1 to forestall dementia. “She was very wholesome and had optimized her way of life, food plan, sleep and stress administration,” she says. “We tried it, however she could not tolerate it. She was nauseous and misplaced weight that she did not want.”
On this case, the dangers outweighed the potential advantages, elevating the query of whether or not GLP-1 would supply the identical longevity profit in individuals for whom there isn’t any medical indication for its use.
